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Research Article| Volume 3, ISSUE 1, P44-49, January 02, 1963

β-glucuronidase activity of the aorta in early stages of experimental rabbit atherosclerosis

DOI:https://doi.org/10.1016/S0368-1319(63)80094-0
β-glucuronidase activity of the aorta in early stages of experimental rabbit atherosclerosis
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      Summary

      The effect of daily cholesterol-fat feeding on the β-glucuronidase activity of rabbit aortae was investigated. There was a significant increase in the activity of this enzyme as early as 4 weeks, and also 10 weeks after the beginning of the feeding experiment. An increase in the serum glucosamine level was also observed while the mucoprotein level did not change. It is suggested that these findings reflect early metabolic changes in the aortic connective tissue of cholesterol-fat fed rabbits.

      Résumé

      L'effet d'un régime au cholestérol sur 1'activité de la glucuronidase-β dans l'aorte de lapin a été étudié. Il y avait une montée significative de l'activité de cette enzyme dés la 4-ième semaine et aussi dès la 10-ième semaine de l'expérimentation. On observa aussi une augmentation du taux de la glucosamine sérique, tandis que le taux des mucoprotéines ne changea pas. Il est suggéré que ces constatations traduisent des modifications métaboliques précoces dans le tissu conjonctif de l'aorte chez le lapin nourri avec du cholestérol.

      Zusammenfassung

      Untersucht wurde die Wirkung die eine tägliche Cholesterin-Fett Fütterung auf die β-Glukuronidaseaktivität der Kaninchenaorta hatte. Die Aktivität dieses Enzyms war bereits 4 Wochen, und auch 10 Wochen nach Beginn des Fütterungsexperiments signifikant erhöht. Auch eine Erhöhung des Serumglukosaminspiegels wurde beobachtet während der Mukoproteinspiegel unverändert blieb. Man darf vermuten, dass these Ergebnisse auf frühe Stoffwechselveränderungen im Aortenbindegewebe von mit Cholesterin-Fett gefütterten Kaninchen hinweisen.
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      Article info

      Publication history

      Received: October 20, 1962

      Identification

      DOI: https://doi.org/10.1016/S0368-1319(63)80094-0

      Copyright

      © 1963 Published by Elsevier Inc.

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