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Summary
Atherosclerosis begins in childhood with the appearance of aortic fatty streaks. Aortic
fatty streaks of some degree are present in practically all individuals from every
human population that has been studied. The average amount of aortic intimai surface
involved with fatty streaks does not differ much among human populations.
Coronary fatty streaks begin to form in adolescence. Most persons 20-29 years of age
have coronary fatty streaks of some degree, even if they are from low socioeconomic
strata.
While fatty streaking is clinically harmless and potentially reversible, the progression
of fatty streaks to more advanced lesions is a critical stage of atherosclerosis.
This conversion takes place at earlier ages in populations with high morbidity and
mortality from coronary heart disease.
The development of fibrous plaques begins in the twenties. Therefore, even though
control programs which attempt to reduce coronary heart disease by preventing atherosclerosis
may meet some success when applied to middle-aged persons, these programs should be
directed toward individuals in the twenties and thirties for maximum benefits. Dietary
habits that retard atherosclerosis should be established in childhood.
Key words
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References
- Atherosclerosis — A pediatric nutrition problem?.Amer. J. clin. Nutr. 1961; 9: 565
- Fatty streaks in the intima of arteries.J. Path. Bad. 1911; 16: 211
- Untersuchungen über Atherosklerose, Teil 1 (Über die Aortaverfettung bei Kindern).Vichows Arch. path. Anat. 1925; 255: 677
- Juvenile arteriosclerosis.Arch. Path. 1930; 10: 417
- Die Veränderungen der Aorta bei Kindern und ihr Verhältnis zur Atherosklerose.Virchows Arch. path. Anat. 1939; 303: 265
- The natural history of atherosclerosis: The early aortic lesions as seen in New Orleans in the middle of the 20th century.Amer. J. Path. 1968; 34: 209
- The natural history of aortic atherosclerosis: relationship to race, sex, and coronary lesions in New Orleans.Exp. mol. Path. 1963; : 15
- The natural history of coronary atherosclerosis.Amer. J. Path. 1962; 40: 37
- The natural history of atherosclerosis: comparison of early aortic lesions in New Orleans, Guatemala, and Costa Rica.Amer. J. Path. 1958; 34: 731
- The early lesions of aortic atherosclerosis in Cali, Colombia.Arch. Path. 1959; 67: 618
- Atherosclerosis in the Bantu.Circulation. 1959; 20: 118
- Atherosclerosis in Puerto Rico.Arch. Path. 1961; 72: 367
- The geographic pathology of atheroclerosis.Lab. Invest. 1968; 18: 463
- Distribution of coronary and aortic atherosclerosis by geographic location, race and sex.Lab. Invest. 1968; 18: 49
- Autopsied cases by age, sex and “race”.Lab. Invest. 1968; 18: 8
- Selected méthodologic aspects of the international atherosclerosis project.Lab. Invest. 1968; 18: 19
- Histologic characteristics of coronary artery fatty streaks.Lab. Invest. 1968; 18: 105
- Fatty streaks in the coronary arteries and aorta.Lab. Invest. 1968; 18: 100
- Topography of atherosclerosis in the coronary arteries.Lab. Invest. 1968; 18: 126
Article Info
Publication History
Received:
October 24,
1968
Identification
Copyright
© 1969 Elsevier Publishing Company, Amsterdam. Published by Elsevier Inc.