March 2009

Editorial Board
Published in issue: March 2009
iii

Reviews

Molecular basis of PCSK9 function
• Gilles Lambert,
• Francesca Charlton,
• Kerry-Anne Rye,
• Derek E. Piper
Published online: July 24, 2008
p1-7

Nutritional and nutraceutical approaches to dyslipidemia and atherosclerosis prevention: Focus on dietary proteins
• Cesare R. Sirtori,
• Claudio Galli,
• James W. Anderson,
• Anna Arnoldi
Published online: August 07, 2008
p8-17

New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism
• Laura Calpe-Berdiel,
• Joan Carles Escolà-Gil,
• Francisco Blanco-Vaca
Published online: August 11, 2008
p18-31

Letters to the Editor

Commentary PCSK9 variants: A new database
• Sarah E.A. Leigh,
• Trond P. Leren,
• Steve E. Humphries
Published in issue: March 2009
p32-33

Resistin: TWEAKing angiogenesis
• Stephanie A. Robertson,
• Colin J. Rae,
• Annette Graham
Published online: July 03, 2008
p34-37

Plasma levels of β₂-microglobulin, a biomarker of peripheral arterial disease, are not affected by maximal leg exercise in patients with intermittent claudication
• Chiara Busti,
• Rino Migliacci,
• Emanuela Falcinelli,
• Paolo Gresele
Published online: August 04, 2008
p38-40

Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes
• M.S. Cunnington,
• B.M. Mayosi,
• D.H. Hall,
• P.J. Avery,
• M. Farrall,
• M.A. Vickers,
• H. Watkins,
• B. Keavney
Published online: August 04, 2008
p41-44
Open Access
LDL-3 fraction levels in patients with unstable angina: Assessment by anion-exchange high-performance liquid chromatography
• Reiko Ohmori,
• Yukihiko Momiyama,
• Nobukiyo Tanaka,
• Ryuichi Kato,
• Hiroaki Taniguchi,
• Haruo Nakamura,
• Fumitaka Ohsuzu
Published online: August 08, 2008
p45-46
Variability of arterial wall shear stress, its dependence on vessel diameter and implications for Murray's Law
• Morton H. Friedman
Published online: August 20, 2008
p47-48
Serum gamma-glutamyltransferase is not associated to peripheral arterial disease in type 2 diabetic patients: Cross-sectional findings
• Cristina Bianchi,
• Giuseppe Penno,
• Stefano Del Prato,
• Roberto Miccoli
Published online: August 20, 2008
p49-50

Basic Research

Vascular Biology, Hemostasis and Oxidative Stress


Vascular protective effects of ezetimibe in ApoE-deficient mice
• Hironori Nakagami,
• Mariana Kiomy Osako,
• Yoichi Takami,
• ...
• Hiroki Hayashi,
• Hideo Shimizu,
• Ryuichi Morishita
Published online: July 07, 2008
p51-58

Differential anti-atherosclerotic effects in the innominate artery and aortic sinus by the liver X receptor agonist T0901317
• Dacheng Peng,
• Richard A. Hiipakka,
• Catherine A. Reardon,
• Godfrey S. Getz,
• Shutsung Liao
Published online: July 21, 2008
p59-66

C-reactive protein stimulates superoxide anion release and tissue factor activity in vivo
• Sridevi Devaraj,
• Mohan R. Dasu,
• Uma Singh,
• L. Vijaya Mohan Rao,
• Ishwarlal Jialal
Published online: July 14, 2008
p67-74

Newly developed PPAR-α agonist (R)-K-13675 inhibits the secretion of inflammatory markers without affecting cell proliferation or tube formation
• Ken Kitajima,
• Shin-ichiro Miura,
• Yoshino Mastuo,
• Yoshinari Uehara,
• Keijiro Saku
Published online: July 08, 2008
p75-81

Neither antioxidants nor genistein inhibit the progression of established atherosclerotic lesions in older apoE deficient mice
• Michelle M. Averill,
• Brian J. Bennett,
• Marcello Rattazzi,
• ...
• Elizabeth A. Kirk,
• Stephen M. Schwartz,
• Michael E. Rosenfeld
Published online: July 30, 2008
p82-88

Physical factors that trigger cholesterol crystallization leading to plaque rupture
• Ameeth Vedre,
• Dorothy R. Pathak,
• Martin Crimp,
• Chee Lum,
• Manoochehr Koochesfahani,
• George S. Abela
Published online: August 14, 2008
p89-96

Ghrelin inhibits contraction and proliferation of human aortic smooth muscle cells by cAMP/PKA pathway activation
• Fabio Rossi,
• Antonella Castelli,
• Maria J. Bianco,
• Cora Bertone,
• Marina Brama,
• Vittorio Santiemma
Published online: July 31, 2008
p97-104

Homocysteine stimulates antioxidant response element-mediated expression of glutamate-cysteine ligase in mouse macrophages
• Florian Bea,
• Francesca N. Hudson,
• Haley Neff-LaFord,
• ...
• Erwin Blessing,
• Hugo A. Katus,
• Michael E. Rosenfeld
Published online: August 08, 2008
p105-111

A proteomic approach to differentiate histologically classified stable and unstable plaques from human carotid arteries
• Antonio J. Lepedda,
• Antonio Cigliano,
• Gian Mario Cherchi,
• ...
• Celina Edelstein,
• Angelo M. Scanu,
• Marilena Formato
Published online: August 20, 2008
p112-118

Metabolism: Lipids, Lipoproteins, Carbohydrates, Homocysteine and Cholesterol


Alterations in the transfer of phospholipids from very-low density lipoproteins to activated platelets in type 2 diabetes
• Salam Ibrahim,
• Nicolas Guillot,
• Valérie Pruneta-Deloche,
• ...
• Philippe Moulin,
• Michel Lagarde,
• Gabriel Ponsin
Published online: July 11, 2008
p119-125

Ethnic variation in levels of circulating IgG autoantibodies to oxidised low-density lipoprotein
• Michelle A. Miller,
• Pasquale Strazzullo,
• Sharada Karanam,
• Francesco P. Cappuccio
Published online: July 08, 2008
p126-136

Reconstituted high-density lipoprotein attenuates postinfarction left ventricular remodeling in rats
• Yoshihiro Kiya,
• Shin-ichiro Miura,
• Satoshi Imaizumi,
• ...
• Hidenori Urata,
• Kerry-Anne Rye,
• Keijiro Saku
Published online: July 08, 2008
p137-144
Plasma enterolignans are not associated with nonfatal myocardial infarction risk
• Anneleen Kuijsten,
• H. Bas Bueno-de-Mesquita,
• Jolanda M.A. Boer,
• ...
• Frans J. Kok,
• Pieter van’t Veer,
• Peter C.H. Hollman
Published online: August 07, 2008
p145-152

Update of Japanese common LDLR gene mutations and their phenotypes: Mild type mutation L547V might predominate in the Japanese population
• Yasuko Miyake,
• Taku Yamamura,
• Naohiko Sakai,
• Toshiyuki Miyata,
• Yoshihiro Kokubo,
• Akira Yamamoto
Published online: August 22, 2008
p153-160

Mutation S462P in the PCSK9 gene reduces secretion of mutant PCSK9 without affecting the autocatalytic cleavage
• Jamie Cameron,
• Øystein L. Holla,
• Jon K. Laerdahl,
• Mari Ann Kulseth,
• Knut Erik Berge,
• Trond P. Leren
Published online: November 20, 2008
p161-165

Degradation of LDLR protein mediated by ‘gain of function’ PCSK9 mutants in normal and ARH cells
• Tommaso Fasano,
• Xi-Ming Sun,
• Dilipkumar D. Patel,
• Anne K. Soutar
Published online: December 11, 2008
p166-171

Clinical and Populatiion Research

Imaging and Measurement of Vessel Health

Sex differences in peripheral artery intima, media and intima media thickness in children and adolescents
• Walter Osika,
• Frida Dangardt,
• Scott M. Montgomery,
• Reinhard Volkmann,
• Li Ming Gan,
• Peter Friberg
Published online: July 07, 2008
p172-177

The delta fractional flow reserve can predict lesion severity and long-term prognosis
• Sinan Altan Kocaman,
• Asife Sahinarslan,
• Uğur Arslan,
• Timur Timurkaynak
Published online: July 23, 2008
p178-184

Vascular reactivity in patients with undifferentiated connective tissue diseases
• Marta Mosca,
• Agostino Virdis,
• Chiara Tani,
• ...
• Antonio Salvetti,
• Stefano Taddei,
• Stefano Bombardieri
Published online: August 08, 2008
p185-191

Genetics


Relationship of the ApoE polymorphism to plasma lipid traits among South Asians, Chinese, and Europeans living in Canada
• Debika Burman,
• Andrew Mente,
• Robert A. Hegele,
• Shofiqul Islam,
• Salim Yusuf,
• Sonia S. Anand
Published online: July 28, 2008
p192-200
Haplotypes of the interleukin-1 receptor antagonist gene, interleukin-1 receptor antagonist mRNA levels and the risk of myocardial infarction
• Rick van Minkelen,
• Stephanie Bezzina Wettinger,
• Marieke C.H. de Visser,
• ...
• Frits R. Rosendaal,
• Rogier M. Bertina,
• Carine J.M. Doggen
Published online: August 14, 2008
p201-205

Epidemiology, Biomarkers and Nutrition


Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals
• Michael Lefevre,
• Leanne M. Redman,
• Leonie K. Heilbronn,
• ...
• Steven R. Smith,
• Eric Ravussin
• for the Pennington CALERIE team
Published online: July 07, 2008
p206-213

Carbohydrate intake modifies associations between ANGPTL4[E40K] genotype and HDL-cholesterol concentrations in White men from the Atherosclerosis Risk in Communities (ARIC) study
• Jennifer A. Nettleton,
• Kelly A. Volcik,
• Ron C. Hoogeveen,
• Eric Boerwinkle
Published online: July 03, 2008
p214-220

Smoking cessation and subclinical atherosclerosis—Results from the Heinz Nixdorf Recall Study
• Karl-Heinz Jöckel,
• Nils Lehmann,
• Beate Roxanne Jaeger,
• ...
• Lothar Volbracht,
• Johannes Siegrist,
• Raimund Erbel
Published online: July 07, 2008
p221-227

Prediction of long-term functional outcome in patients with acute ischemic non-embolic stroke
• John Protopsaltis,
• Stelios Kokkoris,
• Panagiotis Korantzopoulos,
• ...
• Stavros Antonopoulos,
• Andreas Melidonis,
• Grigorios Giannoulis
Published online: July 07, 2008
p228-235
High serum uric acid and low-grade inflammation are associated with smaller LDL and HDL particles
• Jelena Vekic,
• Zorana Jelic-Ivanovic,
• Vesna Spasojevic-Kalimanovska,
• ...
• Aleksandra Zeljkovic,
• Natasa Bogavac-Stanojevic,
• Slavica Spasic
Published online: July 07, 2008
p236-242
Circulating oxidized LDL, measured with FOH1a/DLH3 antibody, is associated with metabolic syndrome and the coronary heart disease risk score in healthy Japanese
• Tetsuya Ueba,
• Shosaku Nomura,
• Tomofumi Nishikawa,
• Motohiro Kajiwara,
• Kohsuke Yamashita
Published online: July 21, 2008
p243-248

Interaction of gender, hypertension, and the angiotensinogen gene haplotypes on the risk of coronary artery disease in a large angiographic cohort
• Chia-Ti Tsai,
• Juey-Jen Hwang,
• Ling-Ping Lai,
• Yi-Chih Wang,
• Jiunn-Lee Lin,
• Fu-Tien Chiang
Published online: July 24, 2008
p249-256
Association between lipid profile and circulating concentrations of estrogens in young men
• Maciej Tomaszewski,
• Fadi J. Charchar,
• Christine Maric,
• ...
• Wladyslaw Grzeszczak,
• Nilesh J. Samani,
• Ewa Zukowska-Szczechowska
Published online: July 21, 2008
p257-262
Cardiorespiratory fitness and coronary artery calcification in young adults: The CARDIA Study
• Chong-Do Lee,
• David R. Jacobs Jr.,
• Arlene Hankinson,
• Carlos Iribarren,
• Stephen Sidney
Published online: July 24, 2008
p263-268
Hypothyroidism is not associated with increased carotid atherosclerosis when cardiovascular risk factors are accounted for in hyperlipidemic patients
• Françoise Chiche,
• Christel Jublanc,
• Mathieu Coudert,
• Valérie Carreau,
• Jean-François Kahn,
• Eric Bruckert
Published online: July 24, 2008
p269-276

Nuchal thickness of subcutaneous adipose tissue is tightly associated with an increased LMW/total adiponectin ratio in obese juveniles
• Harald Mangge,
• Gunter Almer,
• Samih Haj-Yahya,
• ...
• Stefan Pilz,
• Reinhard Möller,
• Renate Horejsi
Published online: July 28, 2008
p277-283

Association of plasma phytosterol concentrations with incident coronary heart disease
Data from the CORA study, a case–control study of coronary artery disease in women
• Eberhard Windler,
• Birgit-Christiane Zyriax,
• Folkert Kuipers,
• Jakob Linseisen,
• Heiner Boeing
Published online: July 28, 2008
p284-290

Investigation of hepatic gluconeogenesis pathway in non-diabetic Asian Indians with non-alcoholic fatty liver disease using in vivo (³¹P) phosphorus magnetic resonance spectroscopy
• Rajeev Sharma,
• Sanjeev Sinha,
• K.A. Danishad,
• ...
• N.R. Jagannathan,
• R.M. Pandey,
• Anoop Misra
Published online: August 04, 2008
p291-297
Relationships between serum fatty acid composition and multiple markers of inflammation and endothelial function in an elderly population
• Helena Petersson,
• Lars Lind,
• Johannes Hulthe,
• Anders Elmgren,
• Tommy Cederholm,
• Ulf Risérus
Published online: August 07, 2008
p298-303

Smoking, smoking cessation and inflammatory markers in older Chinese men: The Guangzhou Biobank Cohort Study
• Xiang Qian Lao,
• Chao Qiang Jiang,
• Wei Sen Zhang,
• ...
• Tai Hing Lam,
• Kar Keung Cheng,
• G. Neil Thomas
Published online: August 11, 2008
p304-310
Lifestyle and environmental factors associated with inflammation, oxidative stress and insulin resistance in children
• Roya Kelishadi,
• Nourollah Mirghaffari,
• Parinaz Poursafa,
• Samuel S. Gidding
Published online: August 11, 2008
p311-319
Small dense low-density lipoprotein in familial combined hyperlipidemia: Independent of metabolic syndrome and related to history of cardiovascular events
• Paolo Pauciullo,
• Marco Gentile,
• Gennaro Marotta,
• ...
• Fulvio Faccenda,
• Salvatore Panico,
• Paolo Rubba
Published online: September 01, 2008
p320-324