December 2020

Editorial board
Published in issue: December 2020
iii-iv

Editorials

Addressing atherosclerotic cardiovascular disease risk in South Asians: A daunting task ahead
• Milan Gupta
Published online: November 03, 2020
p76-78
The enigma to best screen, evaluate and diagnose peripheral artery disease
• Gerald Seinost,
• Clemens HÖBAUS,
• Gerit-Holger Schernthaner
Published online: November 09, 2020
p79-80

Reviews

Polyvascular disease: A narrative review of current evidence and a consideration of the role of antithrombotic therapy
• E. Hope Weissler,
• W. Schuyler Jones,
• Ileana Desormais,
• ...
• Henrik Sillesen,
• Victor Aboyans,
• Manesh R. Patel
Published online: November 06, 2020
p10-17

Physical activity and exercise improve retinal microvascular health as a biomarker of cardiovascular risk: A systematic review
• Lukas Streese,
• Chiara Guerini,
• Lucia Bühlmayer,
• ...
• Svea Bade,
• Arne Deiseroth,
• Henner Hanssen
Published online: September 22, 2020
p33-42
Open Access

The accuracy of toe brachial index and ankle brachial index in the diagnosis of lower limb peripheral arterial disease: A systematic review and meta-analysis
• Ángel Herraiz-Adillo,
• Iván Cavero-Redondo,
• Celia Álvarez-Bueno,
• Diana P. Pozuelo-Carrascosa,
• Montserrat Solera-Martínez
Published online: September 30, 2020
p81-92

Review Series: Endothelial Barrier

Surmounting the endothelial barrier for delivery of drugs and imaging tracers
• Johan G. Schnitzler,
• Kim E. Dzobo,
• Nick S. Nurmohamed,
• Erik S.G. Stroes,
• Jeffrey Kroon
Published online: May 10, 2020
p93-101

Actin remodelling of the endothelium during transendothelial migration of leukocytes
• Abraham C.I. van Steen,
• Werner J. van der Meer,
• Imo E. Hoefer,
• Jaap D. van Buul
Published online: July 04, 2020
p102-110

Transendothelial transport of lipoproteins
• Erika Jang,
• Jerome Robert,
• Lucia Rohrer,
• Arnold von Eckardstein,
• Warren L. Lee
Published online: September 25, 2020
p111-125

Basic Research

Regulation of intestinal LDLR by the LXR-IDOL axis
• Nienke M. van Loon,
• Suzanne A.E. van Wouw,
• Roelof Ottenhoff,
• ...
• Saskia Scheij,
• Martina Moeton,
• Noam Zelcer
Published online: November 09, 2020
p1-9
Open Access

CREB/ATF3 signaling mediates indoxyl sulfate-induced vascular smooth muscle cell proliferation and neointimal formation in uremia
• Wei-Jan Chen,
• Ying-Ju Lai,
• Jia-Lin Lee,
• Sheng-Tang Wu,
• Yu-Juei Hsu
Published online: November 07, 2020
p43-54

Translational Research

Statin therapy reduces plasma angiopoietin-like 3 (ANGPTL3) concentrations in hypercholesterolemic patients via reduced liver X receptor (LXR) activation
• Laurens F. Reeskamp,
• Tycho R. Tromp,
• Roeland Huijgen,
• Erik S.G. Stroes,
• G. Kees Hovingh,
• Aldo Grefhorst
Published online: November 17, 2020
p68-75
Open Access

Clinical & Population Research

Circulating angiopoietin-like protein 2 levels and arterial stiffness in patients receiving maintenance hemodialysis: A cross-sectional study
• Hirotaka Fukami,
• Jun Morinaga,
• Yusuke Okadome,
• ...
• Tetsuya Tajiri,
• Yuichi Oike,
• Masashi Mukoyama
Published online: November 01, 2020
p18-23

Glycerol kinase deficiency in adults: Description of 4 novel cases, systematic review and development of a clinical diagnostic score
• Itziar Lamiquiz-Moneo,
• Rocio Mateo-Gallego,
• Jacinto Fernández-Pardo,
• ...
• Estibaliz Jarauta,
• Ana Cenarro,
• Fernando Civeira
Published online: November 01, 2020
p24-32

Duration of dual antiplatelet therapy after myocardial infarction: Insights from a pooled database of the SMART-DATE and DAPT-STEMI trials
• Elvin Kedhi,
• Ronak Delewi,
• Enrico Fabris,
• ...
• Young Bin Song,
• Hyeon-Cheol Gwon,
• Joo-Yong Hahn
Published online: November 08, 2020
p55-61

Longitudinal effects of smoking cessation on carotid artery atherosclerosis in contemporary smokers: The Wisconsin Smokers Health Study
• James H. Stein,
• Stevens S. Smith,
• Kristin M. Hansen,
• ...
• Megan E. Piper,
• Michael C. Fiore,
• Timothy B. Baker
Published online: November 15, 2020
p62-67

South Asian ethnicity as a risk factor for coronary heart disease
• Seema Pursnani,
• Maqdooda Merchant
Published online: October 09, 2020
p126-130

Sex differences in cardiovascular morbidity associated with familial hypercholesterolaemia: A retrospective cohort study of the UK Simon Broome register linked to national hospital records
• Barbara Iyen,
• Nadeem Qureshi,
• Stephen Weng,
• ...
• Handrean Soran,
• Andrew Neil,
• Steve E. Humphries
Published online: October 30, 2020
p131-137
Open Access

Normalized wall index, intraplaque hemorrhage and ulceration of carotid plaques correlate with the severity of ischemic stroke
• Xin Cao,
• Qingluan Yang,
• Ye Tang,
• ...
• Zekuan Yu,
• Daoying Geng,
• Jun Zhang
Published online: November 05, 2020
p138-144

Correspondence

Translating science into guidance on the management of dyslipidaemias
• Guy G. De Backer
Published online: November 04, 2020
p145-147

Obituary

In memoriam: Christian Ehnholm
• Matti Jauhiainen,
• Vesa M. Olkkonen
Published online: November 21, 2020
p148-149

EAS 2020 ABSTRACTS: ORAL COMMUNICATIONS

Chromatin modifications by the methyltransferase SETD7 modulate angiogenic response in diabetes: Insights for epigenetic-based therapies
• S.A. Mohammed,
• S. Costantino,
• A. Akhmedov,
• ...
• G. Spinetti,
• T.F. Lüscher,
• F. Paneni
Published in issue: December 2020
e2

Deletion of hepatic NCOR1 confers atheroprotection
• S. Oppi,
• S. Nusser-Stein,
• T.F. Lüscher,
• M.H. Oosterveer,
• S. Stein
Published in issue: December 2020
e2

Switching macrophage gene expression from inflammation-resolution to hemorrhage-resolution by redirection of activating transcription factor 1 (ATF1) binding by SMARCA4, BACH1 and histone H3K9 acetylation
• Y. Ge,
• L. Cave,
• A. Seneviratne,
• ...
• J.C. Mason,
• D. Haskard,
• J.J. Boyle
Published in issue: December 2020
e2

M2 macrophage exosomes regulate hematopoiesis & resolve inflammation in atherosclerosis via microrna cargo
• L. Bouchareychas,
• P. Duong,
• S. Covarrubias,
• ...
• S. Carpenter,
• K. Van Keuren-Jensen,
• R.L. Raffai
Published in issue: December 2020
e2-e3

Endothelial miRNAs reduce leukocyte adhesion by modulating inflammatory signal transduction pathways
• A. Kratzer,
• H. Giral,
• M. Moobed,
• U. Landmesser
Published in issue: December 2020
e3

The coatomer (COP I) complex limits the cell-surface abundance of the ldl receptor and cellular LDL uptake
• G. Panteloglou,
• P. Zanoni,
• L. Rohrer,
• ...
• N. Dalila,
• W. März,
• A. Von Eckardstein
Published in issue: December 2020
e3

LRP1 derived peptides as a therapeutic strategy in atherosclerosis. Biochemical, in vitro and in vivo studies
• A. Benitez Amaro,
• C. Pallara,
• R. Prades,
• ...
• T. Tarrago,
• J.C. Escolà-Gil,
• V. Llorente Cortes
Published in issue: December 2020
e3-e4

Deletion of the APOCIII gene in knockout rabbits attenuates cholesterol diet-induced hyperlipidemia and protects against atherosclerosis
• H. Yan,
• M. Niimi,
• H. Zhou,
• ...
• Y.E. Chen,
• J. Yao,
• J. Fan
Published in issue: December 2020
e4

Characteristics of monogenic versus polygenic familial hypobetalipoproteinemia
• A. Rimbert,
• D. Coulibaly,
• M. Marrec,
• ...
• P. Moulin,
• B. Cariou,
• M. Di Filippo
Published in issue: December 2020
e4

Genetic inhibition of CETP and risk of dementia, age-related macular degeneration and cardiovascular mortality
• L.T. Nordestgaard,
• B.K. Lauridsen,
• M. Christoffersen,
• ...
• B. Nordestgaard,
• R. Frikke-Schmidt,
• A. Tybjærg-Hansen
Published in issue: December 2020
e4-e5

Association between apolipoprotein B and cardiovascular risk: A meta-analysis of randomized controlled trials
• F. Galimberti,
• A.L. Catapano,
• A.J. Cupido,
• J.L. Katzmann,
• B.A. Ference
Published in issue: December 2020
e5

Specification of ACMG/AMP guidelines for standardized variant interpretation in familial hypercholesterolemia: On behalf of the clingen FH variant curation expert panel
• M.A. Iacocca,
• J.R. Chora,
• T. Freiberger,
• ...
• R.A. Hegele,
• J.W. Knowles,
• M. Bourbon
Published in issue: December 2020
e5

Hypercholesterolemia disrupts the metabolic regulation of hematopoietic stem cell behavior, favoring the production of pro-inflammatory monocytes in patients with familial hypercholesterolemia
• L.C.A. Stiekema,
• L. Willemsen,
• K. Prange,
• ...
• C. Voermans,
• E. Stroes,
• J. Kroon
Published in issue: December 2020
e6

Colchicine inhibits neutrophil extracellular trap formation in acute coronary syndrome patients post percutaneous coronary intervention
• K. Vaidya,
• B.J. Tucker,
• R. Kurup,
• ...
• K.-A. Rye,
• S. Patel,
• B.J. Cochran
Published in issue: December 2020
e6

The role of monocytic glutaredoxin 1 in atherogenesis.
• Y.J. Ahn,
• L. Wang,
• R. Asmis
Published in issue: December 2020
e6

Mitochondrial dysfunction in M2 macrophages differentiated from human non-classical monocytes is linked to foam cell formation
• A. Murphy,
• M.K.S. Lee,
• A. Al-Sharea,
• D. Sviridov
Published in issue: December 2020
e7

Adoptive cell transfer of vasculatropic T regulatory cells dampens the immuno-inflammatory response in the atherosclerotic plaque
• F. Bonacina,
• E. Martini,
• M. Cremonesi,
• ...
• A.L. Catapano,
• M. Kallikourdis,
• D.G. Norata
Published in issue: December 2020
e7


Inclisiran reduces LDL-cholesterol independent of genotype in subjects with heterozygous familial hypercholesterolaemia
• F.J. Raal,
• D. Kallend,
• K.K. Ray,
• ...
• L.A. Leiter,
• U. Landmesser,
• J.J. Kastelein
Published in issue: December 2020
e7-e8


Effect of inclisiran on atherogenic lipoproteins in high-risk primary prevention populations: analysis from the phase III ORION-11 trial
• K.K. Ray,
• D. Kallend,
• L.A. Leiter,
• ...
• P.L. Wijngaard,
• R.S. Wright,
• J.J. Kastelein
Published in issue: December 2020
e8

The efficacy and safety of evinacumab in homozygous familial hypercholesterolaemia (HoFH) patients with little to no low-density lipoprotein receptor (LDLR) activity
• F.J. Raal,
• R.S. Rosenson,
• L.F. Reeskamp,
• ...
• D.A. Gipe,
• R. Pordy,
• D. Gaudet
Published in issue: December 2020
e8


Results of a 52 week open-label phase 2B study to assess long-term safety, immunogenicity and LDL-C efficacy of monthly dosing with LIB003 a novel anti-PCSK9 recombinant fusion protein
• T.A. Turner,
• B. Butcher,
• P. Mangu,
• ...
• R. Fu,
• R. Bakker-Arkema,
• E.A. Stein
Published in issue: December 2020
e9

Bupropion and/or naltrexone are not associated with increased risk of major adverse cardiovascular events: A network meta-analysis of additive effects
• L.S.F. De Carvalho,
• B.M. Luchiari,
• I. Bonilha,
• A. Sposito
Published in issue: December 2020
e9

The prevalence of heterozygous familial hypercholesterolemia in selected regions of the Russian federation
• A.N. Meshkov,
• A.I. Ershova,
• S.A. Shalnova,
• O.M. Drapkina,
• S.A. Boytsov
• Researchers Of The Fh-Esse-Rf Study
Published in issue: December 2020
e9-e10

The HDL synapse: Decoding a complex interaction network of HDL residing proteins and endothelial cell surface receptors
• K. Frey,
• S. Goetze,
• M. Mueller,
• L. Rohrer,
• A. Von Eckardstein,
• B. Wollscheid
Published in issue: December 2020
e10

Sex hormones therapy differentially modulates HDL function in transgender individuals
• M.P. Adorni,
• D.M. Van Velzen,
• F. Zimetti,
• ...
• C. Macchi,
• M. Den Heijer,
• M. Ruscica
Published in issue: December 2020
e10

Phenotyping carotid endarterectomy plaques of patients with elevated levels of lipoprotein(A)
• K.E. Dzobo,
• F. Waissi,
• M. Winkelmeijer,
• D.P.V. De Kleijn,
• E. Stroes,
• J. Kroon
Published in issue: December 2020
e10

Atherogenic lipoprotein(A) increases vascular glycolysis, thereby facilitating inflammation and leukocyte extravasation
• J.G. Schnitzler,
• R.M. Hoogeveen,
• L. Ali,
• ...
• J.L. Witztum,
• E. Stroes,
• J. Kroon
Published in issue: December 2020
e10-e11

The role of the CYP7B1-derived cholesterol metabolites in nash development
• I. Evangelakos,
• A. Worthmann,
• C. John,
• L. Scheja,
• J. Heeren
Published in issue: December 2020
e11

Δ24-Dehydrocholesterol reductase (DHCR24): A novel target for the treatment of nash
• E. Zhou,
• H. Nakashima,
• Z. Li,
• ...
• P. Rensen,
• M. Giera,
• Y. Wang
Published in issue: December 2020
e11